Chemical Proteomics

Chemical proteomics is a nascent field which can be exploited to understand fundamental biological mechanisms, crucial for the better identification of druggable targets for therapeutics discovery. The approach exploits novel chemical methods such as the use of small molecule probes, bio-orthogonal synthetic methods and chemical analysis technology development to (a) annotate cellular protein function; (b) dissect cellular pathways and understand their regulation; (c) identify novel therapeutic targets; (d) elaborate diagnostic probes and (e) validate the mechanisms of drug candidates.

Based in the School of Chemistry you will drive a revolution in proteomics research at Leeds by leading the development of novel chemical proteomic approaches and/or technologies through the Astbury Centre for Structural Molecular Biology, by exploiting existing strengths in structural biology, biophysics, synthesis, high resolution imaging technologies and high-content imaging. You will also develop a collaborative and hypothesis-driven research program exploiting chemical proteomics in biology by collaborating with colleagues in e.g. cancer biology (Leeds CRUK Centre), cardiovascular science (MCRC) and plant science.
You will have a superb track record in the development of chemical proteomic methods, and the exploitation of such methods to investigate biological mechanisms in a cellular context.  You will develop a research profile that will contribute to the University’s ambition to excel at REF2020, with a sustained record of internationally excellent (and some world-leading) publications. You would also be expected to submit applications for a personal fellowship (e.g. EPSRC Early Career, ERC Starting or Consolidator) as well as project-based applications both as PI and as a contributing co-I on major collaborative grants within the University and beyond.  You will also participate strongly in the development and delivery of relevant educational material/programmes at undergraduate, Masters and PhD (cohort-based training) level.

You will have significant hold a PhD and have significant proven research experience within the field of chemical proteomics (including evidence of research leadership appropriate to the career stage e.g. lead authorship of significant publications, ability to attract independent funding), the ability to teach at both Undergraduate and Postgraduate level, and a clear and compelling vision for personal academic development.

University Grade 8 (£38,511 to £45,954)

For informal enquiries about the role please contact Professor Adam Nelson, tel: +44 (0)113 343 6502, email:

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